二氢睾酮 ：

又名：5α－二氢睾酮5α－dihydrotestosterone
C19H30O2。亦称17β－羟基-5α-雄[甾]烷-3-酮、二氢睾酮、5α－DHT、或雄烷酮（stanorone）。是睾酮的双键在5α处被还原的甾醇。对附属腺（前列腺、精囊腺等），起着所谓的真的雄性激素的作用。在附属性腺的细胞中存在着形成该甾醇的5α-氢化酶。该甾醇和受体蛋白质在细胞内结合成的复合体进入附属腺的细胞核中，促进新的蛋白质合成。显示出比睾酮稍强的雄性激素作用。5β-体虽在肝脏、鸡冠等中以睾酮形态存在，但是没有雄性激素的作用。5α－二氢睾酮由于3α-羟基甾醇脱氢酶的作用而代谢成为5α-雄烷-3α－17β-二醇排出体外。

Mol. Formula: C19H30O2

Mol. Wt.: 290.45 (anhyd.)

m.p.: 177-179°C

CAS Registry No.: 521-18-6

Chemical Name: (5a,17b)-17-Hydroxy -androstan-3-one

Physical Properties: White photosensitive solid. [a]22

D = +33.5°(c = 0.68, EtOH).

Caution: Due care should be exercised to prevent skin contact, ingestion or inhalation of this compound.

Storage: Store tightly sealed at room temperature, protected from exposure to light.

Solubility: Soluble in ethanol (8.0 mg/ml) or water (< 0.5 mg/ml). Solubility in 45% aqueous (w/v) 2-

hydroxypropyl-b-cyclodextrin (Cat. No. H-107): 4.5 mg/ml.

Disposal: Dissolve or mix the compound with a combustible solvent and burn in a chemical incinerator equipped

with an afterburner and scrubber. This product is controlled by the Drug Enforcement Administration.

Appropriate security must be maintained until the substance is destroyed. Records must be kept which

detail the ultimate disposition of the material.