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研究人员鉴别出为新生免疫细胞提供基本生存因子的细胞，新成果于9月在线发表在《自然—免疫学》期刊上。 一种名为T淋巴细胞的血细胞是在胸腺中出生的，它们能反击侵入身体的病毒和其他感染性病菌。在离开胸腺后，这些细胞在身体中巡游以寻找潜在的外来侵略者。然而，这些T细胞的生存却依赖于周期性对淋巴结的造访，它们在这里被名为白细胞介素7的化学信号所“充电”。 多年来，科学家们早已知道白细胞介素7为新生的T细胞提供了生存信号，但他们一直不清楚白细胞介素7究竟是怎样产生的。 Sanjiv Luther和同事在淋巴结和脾脏中鉴别出一种特定的“纤维网状细胞”，发现它们是白细胞介素7的来源。这些细胞所产生的化学信号能引导T细胞走向它们，并提供阻止T细胞死亡的白细胞介素7，从而让T细胞能够在身体中巡回，检查入侵的敌人。（科学时报） 原始出处: Nature Immunology 8, 1255 - 1265 (2007) Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells Alexander Link1,4, Tobias K Vogt1,4, Stéphanie Favre1, Mirjam R Britschgi1, Hans Acha-Orbea1, Boris Hinz2, Jason G Cyster3 & Sanjiv A Luther1 Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its cellular source in the periphery remains poorly defined. Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibroblastic reticular cells in these organs as the main source of interleukin 7. In vitro, T zone fibroblastic reticular cells were able to prevent the death of naive T lymphocytes but not of B lymphocytes by secreting interleukin 7 and the CCR7 ligand CCL19. Using gene-targeted mice, we demonstrate a nonredundant function for CCL19 in T cell homeostasis. Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4+ and CD8+ T cell homeostasis by providing a limited reservoir of survival factors.
Correspondence to: Sanjiv A Luther1 e-mail: sanjiv.luther@unil.ch |
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